CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein kinase Lck

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P06239
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P06239
LCK_HUMAN
Homo sapiens
Tyrosine-protein kinase Lck

PDB Structure

PDB 1CWE
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
Mikol, V., Baumann, G., Keller, T.H., Manning, U., Zurini, M.G.
J.Mol.Biol.