CATH Domain 1cpyA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.287	Helix Hairpins
	1.10.287.410

Domain Context

CATH Clusters

Superfamily	1.10.287.410
Functional Family	Carboxypeptidase Y

Enzyme Information

3.4.16.5

Carboxypeptidase C.

based on mapping to UniProt P00729

Release of a C-terminal amino acid with broad specificity.

-!- Carboxypeptidases of broad specificity with optimum pH 4.5-6.0, inhibited by the action of diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents. -!- This enzyme is probably also identical to lysosomal tyrosine carboxypeptidase. -!- Belongs to peptidase family S10. -!- Formerly EC 3.4.12.1, EC 3.4.12.12, EC 3.4.16.1, EC 3.4.16.3 and EC 3.4.21.13.

UniProtKB Entries (1)

P00729

CBPY_YEAST

Saccharomyces cerevisiae S288C

Carboxypeptidase Y

PDB Structure

PDB	1CPY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Site-Directed Mutagenesis on (Serine) Carboxypeptidase Y from Yeast. The Significance of Thr 60 and met 398 in Hydrolysis and Aminolysis Reactions Sorensen, S.B., Raaschou-Nielsen, M., Mortensen, U.H., Remington, S.J., Breddam, K. J.Am.Chem.Soc.