CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Cytidylate kinase

Enzyme Information

2.7.4.25
(d)CMP kinase.
based on mapping to UniProt P0A6I0
ATP + (d)CMP = ADP + (d)CDP.
-!- The prokaryotic cytidine monophosphate kinase specifically phosphorylates CMP (or dCMP), using ATP as the preferred phosphoryl donor. -!- Unlike EC 2.7.4.14, a eukaryotic enzyme that phosphorylates UMP and CMP with similar efficiency, the prokaryotic enzyme phosphorylates UMP with very low rates, and this function is catalyzed in prokaryotes by EC 2.7.4.22. -!- The enzyme phosphorylates dCMP nearly as well as it does CMP.

UniProtKB Entries (1)

P0A6I0
KCY_ECOLI
Escherichia coli K-12
Cytidylate kinase

PDB Structure

PDB 1CKE
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of escherichia coli CMP kinase alone and in complex with CDP: a new fold of the nucleoside monophosphate binding domain and insights into cytosine nucleotide specificity.
Briozzo, P., Golinelli-Pimpaneau, B., Gilles, A.M., Gaucher, J.F., Burlacu-Miron, S., Sakamoto, H., Janin, J., Barzu, O.
Structure