CATH Domain 1ca0G00

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Chymotrypsinogen A

Enzyme Information

3.4.21.1

Chymotrypsin.

based on mapping to UniProt P00766

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

-!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.5 and EC 3.4.4.6.

UniProtKB Entries (2)

P05067	A4_HUMAN Homo sapiens Amyloid-beta precursor protein
P00766	CTRA_BOVIN Bos taurus Chymotrypsinogen A

PDB Structure

PDB	1CA0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Scheidig, A.J., Hynes, T.R., Pelletier, L.A., Wells, J.A., Kossiakoff, A.A. Protein Sci.