CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Glutathione reductase

Enzyme Information

1.8.1.12
Trypanothione-disulfide reductase.
based on mapping to UniProt P28593
Trypanothione + NADP(+) = trypanothione disulfide + NADPH.
-!- Trypanothione disulfide is the oxidized form of N(1),N(8)- bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. -!- The activity is dependent on a redox-active cystine at the active center (cf. EC 1.8.1.7). -!- Formerly EC 1.6.4.8.

UniProtKB Entries (1)

P28593
TYTR_TRYCR
Trypanosoma cruzi
Trypanothione reductase

PDB Structure

PDB 1BZL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors.
Bond, C.S., Zhang, Y., Berriman, M., Cunningham, M.L., Fairlamb, A.H., Hunter, W.N.
Structure Fold.Des.