CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.80
Isopropanol dehydrogenase (NADP(+)).
based on mapping to UniProt P14941
Propan-2-ol + NADP(+) = acetone + NADPH.
-!- Also acts on other short-chain secondary alcohols and, slowly, on primary alcohols.

UniProtKB Entries (1)

P14941
ADH_THEBR
Thermoanaerobacter brockii
NADP-dependent isopropanol dehydrogenase

PDB Structure

PDB 1BXZ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of a thermophilic alcohol dehydrogenase substrate complex suggests determinants of substrate specificity and thermostability.
Li, C., Heatwole, J., Soelaiman, S., Shoham, M.
Proteins