CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P52663
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P52663
BLAN_ENTCL
Enterobacter cloacae
Imipenem-hydrolyzing beta-lactamase

PDB Structure

PDB 1BUE
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
X-ray analysis of the NMC-A beta-lactamase at 1.64-A resolution, a class A carbapenemase with broad substrate specificity.
Swaren, P., Maveyraud, L., Raquet, X., Cabantous, S., Duez, C., Pedelacq, J.D., Mariotte-Boyer, S., Mourey, L., Labia, R., Nicolas-Chanoine, M.H., Nordmann, P., Frere, J.M., Samama, J.P.
J.Biol.Chem.