CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.110 | Butyryl-CoA Dehydrogenase, subunit A; domain 2 |
|
2.40.110.10 | Butyryl-CoA Dehydrogenase, subunit A, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Butyryl-CoA Dehydrogenase, subunit A, domain 2 |
| Functional Family | Acyl-CoA dehydrogenase, mitochondrial |
Enzyme Information
| 1.3.8.1 |
Short-chain acyl-CoA dehydrogenase.
based on mapping to UniProt Q06319
A short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
-!- One of several enzymes that catalyze the first step in fatty acids beta-oxidation. -!- The enzyme catalyzes the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R hydrogen atoms. -!- The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms. -!- The highest activity was reported with either butanoyl-CoA or pentanoyl-CoA. -!- The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA. -!- Cf. EC 1.3.8.7, EC 1.3.8.8 and EC 1.3.8.9. -!- Formerly EC 1.3.2.1 and EC 1.3.99.2.
|
UniProtKB Entries (1)
| Q06319 |
ACDS_MEGEL
Megasphaera elsdenii
Acyl-CoA dehydrogenase, short-chain specific
|
PDB Structure
| PDB | 1BUC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Three-dimensional structure of butyryl-CoA dehydrogenase from Megasphaera elsdenii.
Biochemistry
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