CATH Classification

Domain Context

CATH Clusters

Superfamily Neutral Protease Domain 2
Functional Family

Enzyme Information

3.4.24.29
Aureolysin.
based on mapping to UniProt P81177
Cleavage of insulin B chain with specificity similar to that of thermolysin, preferring hydrophobic P1' residues. Activates the glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus.
-!- Earlier confused with staphylokinase. -!- Belongs to peptidase family M4. -!- Formerly EC 3.4.24.4 and EC 3.4.99.22.

UniProtKB Entries (1)

P81177
AURE_STAAU
Staphylococcus aureus
Zinc metalloproteinase aureolysin

PDB Structure

PDB 1BQB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Amino-acid sequence and three-dimensional structure of the Staphylococcus aureus metalloproteinase at 1.72 A resolution.
Banbula, A., Potempa, J., Travis, J., Fernandez-Catalan, C., Mann, K., Huber, R., Bode, W., Medrano, F.
Structure