CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P00469
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P00469
TYSY_LACCA
Lactobacillus casei
Thymidylate synthase

PDB Structure

PDB 1BO8
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Morse, R.J., Kawase, S., Santi, D.V., Finer-Moore, J., Stroud, R.M.
Biochemistry