CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Cyclin-dependent kinase 6

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt Q00534
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P55273
CDN2D_HUMAN
Homo sapiens
Cyclin-dependent kinase 4 inhibitor D

PDB Structure

PDB 1BI8
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
Russo, A.A., Tong, L., Lee, J.O., Jeffrey, P.D., Pavletich, N.P.
Nature