CATH Classification

Domain Context

CATH Clusters

Superfamily C2 domain
Functional Family Protein kinase C delta type

Enzyme Information

2.7.11.13
Protein kinase C.
based on mapping to UniProt P09215
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P09215
KPCD_RAT
Rattus norvegicus
Protein kinase C delta type

PDB Structure

PDB 1BDY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the C2 domain from protein kinase C-delta.
Pappa, H., Murray-Rust, J., Dekker, L.V., Parker, P.J., McDonald, N.Q.
Structure