CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family Metallo-beta-lactamase type 2

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P04190
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P04190
BLA2_BACCE
Bacillus cereus
Metallo-beta-lactamase type 2

PDB Structure

PDB 1BC2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the zinc-dependent beta-lactamase from Bacillus cereus at 1.9 A resolution: binuclear active site with features of a mononuclear enzyme.
Fabiane, S.M., Sohi, M.K., Wan, T., Payne, D.J., Bateson, J.H., Mitchell, T., Sutton, B.J.
Biochemistry