CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.275 | Fumarase C; Chain B, domain 1 |
|
1.10.275.10 | Fumarase/aspartase (N-terminal domain) |
Domain Context
CATH Clusters
| Superfamily | Fumarase/aspartase (N-terminal domain) |
| Functional Family | Histidine ammonia-lyase |
Enzyme Information
| 4.3.1.3 |
Histidine ammonia-lyase.
based on mapping to UniProt P21310
L-histidine = urocanate + NH(3).
-!- Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.23, EC 4.3.1.24 and EC 4.3.1.25. -!- Catalyzes the first step in the degradation of histidine and the product, urocanic acid, is further metabolized to glutamate.
|
UniProtKB Entries (1)
| P21310 |
HUTH_PSEPU
Pseudomonas putida
Histidine ammonia-lyase
|
PDB Structure
| PDB | 1B8F |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile.
Biochemistry
|
