CATH Classification

Domain Context

CATH Clusters

Superfamily Alkaline Phosphatase, subunit A
Functional Family Alkaline phosphatase

Enzyme Information

3.1.3.1
Alkaline phosphatase.
based on mapping to UniProt P00634
A phosphate monoester + H(2)O = an alcohol + phosphate.
-!- Active at a high pH optimum. -!- Wide specificity. -!- Also catalyzes transphosphorylations. -!- Some enzymes hydrolyze diphosphate (cf. EC 3.6.1.1).

UniProtKB Entries (1)

P00634
PPB_ECOLI
Escherichia coli K-12
Alkaline phosphatase

PDB Structure

PDB 1ANJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
Murphy, J.E., Tibbitts, T.T., Kantrowitz, E.R.
J.Mol.Biol.