CATH Classification

Domain Context

CATH Clusters

Superfamily Hedgehog/Intein (Hint) domain
Functional Family

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P72065
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P72065
GYRA_MYCXE
Mycobacterium xenopi
DNA gyrase subunit A

PDB Structure

PDB 1AM2
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing.
Klabunde, T., Sharma, S., Telenti, A., Jacobs Jr., W.R., Sacchettini, J.C.
Nat.Struct.Biol.