CATH Classification

Domain Context

CATH Clusters

Superfamily Alkaline Phosphatase, subunit A
Functional Family Alkaline phosphatase

Enzyme Information

3.1.3.1
Alkaline phosphatase.
based on mapping to UniProt P00634
A phosphate monoester + H(2)O = an alcohol + phosphate.
-!- Active at a high pH optimum. -!- Wide specificity. -!- Also catalyzes transphosphorylations. -!- Some enzymes hydrolyze diphosphate (cf. EC 3.6.1.1).

UniProtKB Entries (1)

P00634
PPB_ECOLI
Escherichia coli K-12
Alkaline phosphatase

PDB Structure

PDB 1ALH
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Kinetics and crystal structure of a mutant Escherichia coli alkaline phosphatase (Asp-369-->Asn): a mechanism involving one zinc per active site.
Tibbitts, T.T., Xu, X., Kantrowitz, E.R.
Protein Sci.