CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P00519
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00519
ABL1_HUMAN
Homo sapiens
Tyrosine-protein kinase ABL1

PDB Structure

PDB 1AB2
External Links
Method SOLUTION NMR
Organism
Primary Citation
Three-dimensional solution structure of the src homology 2 domain of c-abl.
Overduin, M., Rios, C.B., Mayer, B.J., Baltimore, D., Cowburn, D.
Cell(Cambridge,Mass.)