CATH Classification

Domain Context

CATH Clusters

Superfamily Divalent-metal-dependent TIM barrel enzymes
Functional Family Xylose isomerase

Enzyme Information

5.3.1.5
Xylose isomerase.
based on mapping to UniProt P19148
D-xylopyranose = D-xylulose.
-!- The enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity. -!- The enzyme binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyzes ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. -!- Isomerization proceeds via a hydride-shift mechanism.

UniProtKB Entries (1)

P19148
XYLA_THETU
Thermoanaerobacterium thermosulfurigenes
Xylose isomerase

PDB Structure

PDB 1A0C
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structures of Class II Xylose Isomerases from Two Thermophiles and a Hyperthermophile
Gallay, O., Chopra, R., Conti, E., Brick, P., Jackson, R., Hartley, B., Vieille, C., Zeikus, J.G., Blow, D.
To be Published