PDB Information

PDB6MT0
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.
Wang, H.L., Andrews, K.L., Booker, S.K., Canon, J., Cee, V.J., Chavez Jr., F., Chen, Y., Eastwood, H., Guerrero, N., Herberich, B., Hickman, D., Lanman, B.A., Laszlo 3rd., J., Lee, M.R., Lipford, J.R., Mattson, B., Mohr, C., Nguyen, Y., Norman, M.H., Pettus, L.H., Powers, D., Reed, A.B., Rex, K., Sastri, C., Tamayo, N., Wang, P., Winston, J.T., Wu, B., Wu, Q., Wu, T., Wurz, R.P., Xu, Y., Zhou, Y., Tasker, A.S.
J. Med. Chem.
HeaderTransferase
Released2018-10-18
Resolution2.200
CATH Insert Date20 Jan, 2019

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 20 Jan, 2019 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
6mt0A01 21 Jan, 2019 3.30.200.20 Assigned
6mt0A02 21 Jan, 2019 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P11309 PIM1_HUMAN Homo sapiens Serine/threonine-protein kinase pim-1