PDB 6ivx

PDB Information

PDB6IVX
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.
Kotoku, M., Maeba, T., Fujioka, S., Yokota, M., Seki, N., Ito, K., Suwa, Y., Ikenogami, T., Hirata, K., Hase, Y., Katsuda, Y., Miyagawa, N., Arita, K., Asahina, K., Noguchi, M., Nomura, A., Doi, S., Adachi, T., Crowe, P., Tao, H., Thacher, S., Hashimoto, H., Suzuki, T., Shiozaki, M.
J. Med. Chem.
HeaderNuclear Protein/Inhibitor
Released2018-12-04
Resolution2.350
CATH Insert Date10 Mar, 2019

PDB Images (13)

PDB Prints

PDB Chains (8)

Chain ID Date inserted into CATH CATH Status
A 10 Mar, 2019 Chopped
B 10 Mar, 2019 Rejected
C 10 Mar, 2019 Chopped
D 10 Mar, 2019 Rejected
E 10 Mar, 2019 Chopped
F 10 Mar, 2019 Rejected
G 10 Mar, 2019 Chopped
H 10 Mar, 2019 Rejected

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
6ivxA00 11 Mar, 2019 1.10.565.10 Assigned
6ivxC00 11 Mar, 2019 1.10.565.10 Assigned
6ivxE00 11 Mar, 2019 1.10.565.10 Assigned
6ivxG00 11 Mar, 2019 1.10.565.10 Assigned

UniProtKB Entries (8)

Accession Gene ID Taxon Description
P51449 RORG_HUMAN Homo sapiens Nuclear receptor ROR-gamma
Q9Y618 NCOR2_HUMAN Homo sapiens Nuclear receptor corepressor 2
Q9Y618 NCOR2_HUMAN Homo sapiens Nuclear receptor corepressor 2
P51449 RORG_HUMAN Homo sapiens Nuclear receptor ROR-gamma
Q9Y618 NCOR2_HUMAN Homo sapiens Nuclear receptor corepressor 2
Q9Y618 NCOR2_HUMAN Homo sapiens Nuclear receptor corepressor 2
P51449 RORG_HUMAN Homo sapiens Nuclear receptor ROR-gamma
P51449 RORG_HUMAN Homo sapiens Nuclear receptor ROR-gamma
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