PDB 6huu

PDB Links
Overview

PDB Information

PDB	6HUU
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-09
Resolution	2.800
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6huu

PDB 6huu

6huua

PDB Chain 6huua

6huuA

PDB Chain 6huuA

6huub

PDB Chain 6huub

6huuB

PDB Chain 6huuB

6huuC

PDB Chain 6huuC

6huuD

PDB Chain 6huuD

6huuE

PDB Chain 6huuE

6huuF

PDB Chain 6huuF

6huuG

PDB Chain 6huuG

6huuH

PDB Chain 6huuH

6huuI

PDB Chain 6huuI

6huuJ

PDB Chain 6huuJ

6huuK

PDB Chain 6huuK

6huuL

PDB Chain 6huuL

6huuM

PDB Chain 6huuM

6huuN

PDB Chain 6huuN

6huuO

PDB Chain 6huuO

6huuP

PDB Chain 6huuP

6huuQ

PDB Chain 6huuQ

6huuR

PDB Chain 6huuR

6huuS

PDB Chain 6huuS

6huuT

PDB Chain 6huuT

6huuU

PDB Chain 6huuU

6huuV

PDB Chain 6huuV

6huuW

PDB Chain 6huuW

6huuX

PDB Chain 6huuX

6huuY

PDB Chain 6huuY

6huuZ

PDB Chain 6huuZ

6huua00

CATH Domain 6huua00

6huuA00

CATH Domain 6huuA00

6huub00

CATH Domain 6huub00

6huuB00

CATH Domain 6huuB00

6huuC00

CATH Domain 6huuC00

6huuD00

CATH Domain 6huuD00

6huuE00

CATH Domain 6huuE00

6huuF00

CATH Domain 6huuF00

6huuG00

CATH Domain 6huuG00

6huuH00

CATH Domain 6huuH00

6huuI00

CATH Domain 6huuI00

6huuJ00

CATH Domain 6huuJ00

6huuK00

CATH Domain 6huuK00

6huuL00

CATH Domain 6huuL00

6huuM00

CATH Domain 6huuM00

6huuN00

CATH Domain 6huuN00

6huuO00

CATH Domain 6huuO00

6huuP00

CATH Domain 6huuP00

6huuQ00

CATH Domain 6huuQ00

6huuR00

CATH Domain 6huuR00

6huuS00

CATH Domain 6huuS00

6huuT00

CATH Domain 6huuT00

6huuU00

CATH Domain 6huuU00

6huuV00

CATH Domain 6huuV00

6huuW00

CATH Domain 6huuW00

6huuX00

CATH Domain 6huuX00

6huuY00

CATH Domain 6huuY00

6huuZ00

CATH Domain 6huuZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6huua00	04 Feb, 2019	3.60.20.10	Assigned
6huuA00	04 Feb, 2019	3.60.20.10	Assigned
6huub00	04 Feb, 2019	3.60.20.10	Assigned
6huuB00	04 Feb, 2019	3.60.20.10	Assigned
6huuC00	04 Feb, 2019	3.60.20.10	Assigned
6huuD00	04 Feb, 2019	3.60.20.10	Assigned
6huuE00	04 Feb, 2019	3.60.20.10	Assigned
6huuF00	04 Feb, 2019	3.60.20.10	Assigned
6huuG00	04 Feb, 2019	3.60.20.10	Assigned
6huuH00	04 Feb, 2019	3.60.20.10	Assigned
6huuI00	04 Feb, 2019	3.60.20.10	Assigned
6huuJ00	04 Feb, 2019	3.60.20.10	Assigned
6huuK00	04 Feb, 2019	3.60.20.10	Assigned
6huuL00	04 Feb, 2019	3.60.20.10	Assigned
6huuM00	04 Feb, 2019	3.60.20.10	Assigned
6huuN00	04 Feb, 2019	3.60.20.10	Assigned
6huuO00	04 Feb, 2019	3.60.20.10	Assigned
6huuP00	04 Feb, 2019	3.60.20.10	Assigned
6huuQ00	04 Feb, 2019	3.60.20.10	Assigned
6huuR00	04 Feb, 2019	3.60.20.10	Assigned
6huuS00	04 Feb, 2019	3.60.20.10	Assigned
6huuT00	04 Feb, 2019	3.60.20.10	Assigned
6huuU00	04 Feb, 2019	3.60.20.10	Assigned
6huuV00	04 Feb, 2019	3.60.20.10	Assigned
6huuW00	04 Feb, 2019	3.60.20.10	Assigned
6huuX00	04 Feb, 2019	3.60.20.10	Assigned
6huuY00	04 Feb, 2019	3.60.20.10	Assigned
6huuZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3