PDB Information

PDB6DCG
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceRattus norvegicus
Primary Citation
MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.
Boga, S.B., Deng, Y., Zhu, L., Nan, Y., Cooper, A.B., Shipps Jr., G.W., Doll, R., Shih, N.Y., Zhu, H., Sun, R., Wang, T., Paliwal, S., Tsui, H.C., Gao, X., Yao, X., Desai, J., Wang, J., Alhassan, A.B., Kelly, J., Patel, M., Muppalla, K., Gudipati, S., Zhang, L.K., Buevich, A., Hesk, D., Carr, D., Dayananth, P., Black, S., Mei, H., Cox, K., Sherborne, B., Hruza, A.W., Xiao, L., Jin, W., Long, B., Liu, G., Taylor, S.A., Kirschmeier, P., Windsor, W.T., Bishop, R., Samatar, A.A.
ACS Med Chem Lett
HeaderTransferase/Transferase Inhibitor
Released2018-05-06
Resolution1.450
CATH Insert Date12 Aug, 2018

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 12 Aug, 2018 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
6dcgA01 13 Aug, 2018 3.30.200.20 Assigned
6dcgA02 13 Aug, 2018 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P63086 MK01_RAT Rattus norvegicus Mitogen-activated protein kinase 1