PDB 6d5w

PDB Links
Overview

PDB Information

PDB	6D5W
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. Hodges, T.R., Abbott, J.R., Little, A.J., Sarkar, D., Salovich, J.M., Howes, J.E., Akan, D.T., Sai, J., Arnold, A.L., Browning, C., Burns, M.C., Sobolik, T., Sun, Q., Beesetty, Y., Coker, J.A., Scharn, D., Stadtmueller, H., Rossanese, O.W., Phan, J., Waterson, A.G., McConnell, D.B., Fesik, S.W. J. Med. Chem.
Header	Signaling Protein
Released	2018-04-19
Resolution	2.480
CATH Insert Date	31 Mar, 2019

PDB Images (8)

Image of CATH 6d5w

6d5w

PDB 6d5w

Image of CATH 6d5wQ

6d5wQ

PDB Chain 6d5wQ

Image of CATH 6d5wR

6d5wR

PDB Chain 6d5wR

Image of CATH 6d5wS

6d5wS

PDB Chain 6d5wS

Image of CATH 6d5wQ00

6d5wQ00

CATH Domain 6d5wQ00

Image of CATH 6d5wR00

6d5wR00

CATH Domain 6d5wR00

Image of CATH 6d5wS01

6d5wS01

CATH Domain 6d5wS01

Image of CATH 6d5wS02

6d5wS02

CATH Domain 6d5wS02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
Q	31 Mar, 2019	Chopped
R	31 Mar, 2019	Chopped
S	31 Mar, 2019	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6d5wQ00	01 Apr, 2019	3.40.50.300	Assigned
6d5wR00	01 Apr, 2019	3.40.50.300	Assigned
6d5wS01	01 Apr, 2019	1.20.870.10	Assigned
6d5wS02	01 Apr, 2019	1.10.840.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
Q07889	SOS1_HUMAN	Homo sapiens	Son of sevenless homolog 1
P01112	RASH_HUMAN	Homo sapiens	GTPase HRas
P01112	RASH_HUMAN	Homo sapiens	GTPase HRas