Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase gamma (PI3K gamma ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS).
Come, J.H., Collier, P.N., Henderson, J.A., Pierce, A.C., Davies, R.J., Le Tiran, A., O'Dowd, H., Bandarage, U.K., Cao, J., Deininger, D., Grey, R., Krueger, E.B., Lowe, D.B., Liang, J., Liao, Y., Messersmith, D., Nanthakumar, S., Sizensky, E., Wang, J., Xu, J., Chin, E.Y., Damagnez, V., Doran, J.D., Dworakowski, W., Griffith, J.P., Jacobs, M.D., Khare-Pandit, S., Mahajan, S., Moody, C.S., Aronov, A.M.
J. Med. Chem.