PDB 6bb2

PDB Information

PDB6BB2
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
Wei, B., Labadie, S.S., Robarge, K., Chen, J., Chen, Z., Corson, L.B., Ding, C.Z., DiPasquale, A.G., Dragovich, P.S., Eigenbrot, C., Evangelista, M., Fauber, B.P., Goa, Z., Ge, H., Hitz, A., Ho, Q., Lai, K.W., Liu, W., Liu, Y., Li, C., Ma, S., Malek, S., O'Brien, T., Pang, J., Peterson, D., Salphati, L., Sideris, S., Ultsch, M., Yen, I., Yue, Q., Zhang, H., Zhou, A., Purkey, H.E.
To Be Published
HeaderOxidoreductase/Inhibitor
Released2017-10-16
Resolution2.470
CATH Insert Date16 Dec, 2018

PDB Images (25)

PDB Prints

PDB Chains (8)

Chain ID Date inserted into CATH CATH Status
A 16 Dec, 2018 Chopped
B 16 Dec, 2018 Chopped
C 16 Dec, 2018 Chopped
D 16 Dec, 2018 Chopped
E 16 Dec, 2018 Chopped
F 16 Dec, 2018 Chopped
G 16 Dec, 2018 Chopped
H 16 Dec, 2018 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
6bb2A01 28 Feb, 2019 3.40.50.720 Assigned
6bb2A02 28 Feb, 2019 3.90.110.10 Assigned
6bb2B01 28 Feb, 2019 3.40.50.720 Assigned
6bb2B02 28 Feb, 2019 3.90.110.10 Assigned
6bb2C01 28 Feb, 2019 3.40.50.720 Assigned
6bb2C02 28 Feb, 2019 3.90.110.10 Assigned
6bb2D01 28 Feb, 2019 3.40.50.720 Assigned
6bb2D02 28 Feb, 2019 3.90.110.10 Assigned
6bb2E01 28 Feb, 2019 3.40.50.720 Assigned
6bb2E02 28 Feb, 2019 3.90.110.10 Assigned
6bb2F01 28 Feb, 2019 3.40.50.720 Assigned
6bb2F02 28 Feb, 2019 3.90.110.10 Assigned
6bb2G01 28 Feb, 2019 3.40.50.720 Assigned
6bb2G02 28 Feb, 2019 3.90.110.10 Assigned
6bb2H01 28 Feb, 2019 3.40.50.720 Assigned
6bb2H02 28 Feb, 2019 3.90.110.10 Assigned

UniProtKB Entries (8)

Accession Gene ID Taxon Description
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain