PDB 5ylj

PDB Information

PDB5YLJ
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceSus scrofa
Primary Citation
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
Yang, J.H., Yan, W., Yu, Y.M., Wang, Y.X., Yang, T., Xue, L.L., Yuan, X., Long, C.F., Liu, Z.W., Chen, X.X., Hu, M.S., Zheng, L., Qiu, Q., Pei, H.Y., Li, D., Wang, F., Bai, P., Wen, J.L., Ye, H.Y., Chen, L.J.
J. Biol. Chem.
HeaderStructural Protein
Released2017-10-17
Resolution2.700
CATH Insert Date03 Jun, 2018

PDB Images (23)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 03 Jun, 2018 Chopped
B 03 Jun, 2018 Chopped
C 03 Jun, 2018 Chopped
D 03 Jun, 2018 Chopped
E 03 Jun, 2018 Chopped
F 03 Jun, 2018 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5yljA01 28 Jun, 2018 3.40.50.1440 Assigned
5yljA02 28 Jun, 2018 3.30.1330.20 Assigned
5yljA03 28 Jun, 2018 1.10.287.600 Assigned
5yljB01 28 Jun, 2018 3.40.50.1440 Assigned
5yljB02 28 Jun, 2018 3.30.1330.20 Assigned
5yljB03 28 Jun, 2018 1.10.287.600 Assigned
5yljC01 28 Jun, 2018 3.40.50.1440 Assigned
5yljC02 28 Jun, 2018 3.30.1330.20 Assigned
5yljC03 28 Jun, 2018 1.10.287.600 Assigned
5yljD01 28 Jun, 2018 3.40.50.1440 Assigned
5yljD02 28 Jun, 2018 3.30.1330.20 Assigned
5yljD03 28 Jun, 2018 1.10.287.600 Assigned
5yljE01 28 Jun, 2018 6.10.280.30 Assigned
5yljF01 28 Jun, 2018 3.40.50.11480 Assigned
5yljF02 28 Jun, 2018 3.30.470.20 Assigned
5yljF03 28 Jun, 2018 3.30.1490.20 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
E1BQ43 E1BQ43_CHICK Gallus gallus Uncharacterized protein
Q2XVP4 TBA1B_PIG Sus scrofa Tubulin alpha-1B chain
Q2XVP4 TBA1B_PIG Sus scrofa Tubulin alpha-1B chain
P63043 STMN4_RAT Rattus norvegicus Stathmin-4
P02554 TBB_PIG Sus scrofa Tubulin beta chain
P02554 TBB_PIG Sus scrofa Tubulin beta chain