PDB 5ygx

PDB Information

PDB5YGX
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine beta-Secretase (BACE1) Inhibitors via Active Conformation Stabilization
Nakahara, K., Fuchino, K., Komano, K., Asada, N., Tadano, G., Hasegawa, T., Yamamoto, T., Sako, Y., Ogawa, M., Unemura, C., Hosono, M., Ito, H., Sakaguchi, G., Ando, S., Ohnishi, S., Kido, Y., Fukushima, T., Dhuyvetter, D., Borghys, H., Gijsen, H.J.M., Yamano, Y., Iso, Y., Kusakabe, K.I.
J. Med. Chem.
HeaderHydrolase/Inhibitor
Released2017-09-27
Resolution2.200
CATH Insert Date12 Aug, 2018

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 12 Aug, 2018 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5ygxA01 13 Aug, 2018 2.40.70.10 Assigned
5ygxA02 13 Aug, 2018 2.40.70.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1