PDB 5xiw

PDB Information

PDB5XIW
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceSus scrofa
Primary Citation
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
Jianhong, Y., Wei, Y., Yamei, Y., Yuxi, W., Tao, Y., Linlin, X., Xue, Y., Caofeng, L., Zuowei, L., Xiaoxin, C., Mengshi, H., Li, Z., Qiang, Q., Heying, P., Dan, L., Fang, W., Peng, B., Jiaolin, W., Haoyu, Y., Lijuan, C.
J. Biol. Chem.
HeaderCell Cycle
Released2017-04-27
Resolution2.900
CATH Insert Date03 Jun, 2018

PDB Images (23)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 03 Jun, 2018 Chopped
B 03 Jun, 2018 Chopped
C 03 Jun, 2018 Chopped
D 03 Jun, 2018 Chopped
E 03 Jun, 2018 Chopped
F 03 Jun, 2018 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5xiwA01 28 Jun, 2018 3.40.50.1440 Assigned
5xiwA02 28 Jun, 2018 3.30.1330.20 Assigned
5xiwA03 28 Jun, 2018 1.10.287.600 Assigned
5xiwB01 28 Jun, 2018 3.40.50.1440 Assigned
5xiwB02 28 Jun, 2018 3.30.1330.20 Assigned
5xiwB03 28 Jun, 2018 1.10.287.600 Assigned
5xiwC01 28 Jun, 2018 3.40.50.1440 Assigned
5xiwC02 28 Jun, 2018 3.30.1330.20 Assigned
5xiwC03 28 Jun, 2018 1.10.287.600 Assigned
5xiwD01 28 Jun, 2018 3.40.50.1440 Assigned
5xiwD02 28 Jun, 2018 3.30.1330.20 Assigned
5xiwD03 28 Jun, 2018 1.10.287.600 Assigned
5xiwE01 28 Jun, 2018 6.10.280.30 Assigned
5xiwF01 28 Jun, 2018 3.40.50.11480 Assigned
5xiwF02 28 Jun, 2018 3.30.470.20 Assigned
5xiwF03 28 Jun, 2018 3.30.1490.20 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
Q2XVP4 TBA1B_PIG Sus scrofa Tubulin alpha-1B chain
E1BQ43 E1BQ43_CHICK Gallus gallus Uncharacterized protein
P63043 STMN4_RAT Rattus norvegicus Stathmin-4
P02554 TBB_PIG Sus scrofa Tubulin beta chain
P02554 TBB_PIG Sus scrofa Tubulin beta chain
Q2XVP4 TBA1B_PIG Sus scrofa Tubulin alpha-1B chain