PDB 5vp0

PDB Links
Overview

PDB Information

PDB	5VP0
Method	X-RAY DIFFRACTION
Host Organism	Baculovirus expression vector pFastBac1-HM
Gene Source	Homo sapiens
Primary Citation	Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders. Mikami, S., Nakamura, S., Ashizawa, T., Nomura, I., Kawasaki, M., Sasaki, S., Oki, H., Kokubo, H., Hoffman, I.D., Zou, H., Uchiyama, N., Nakashima, K., Kamiguchi, N., Imada, H., Suzuki, N., Iwashita, H., Taniguchi, T. J. Med. Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2017-05-03
Resolution	2.200
CATH Insert Date	14 Nov, 2017

PDB Images (7)

Image of CATH 5vp0

5vp0

PDB 5vp0

Image of CATH 5vp0A

5vp0A

PDB Chain 5vp0A

Image of CATH 5vp0B

5vp0B

PDB Chain 5vp0B

Image of CATH 5vp0C

5vp0C

PDB Chain 5vp0C

Image of CATH 5vp0A00

5vp0A00

CATH Domain 5vp0A00

Image of CATH 5vp0B00

5vp0B00

CATH Domain 5vp0B00

Image of CATH 5vp0C00

5vp0C00

CATH Domain 5vp0C00

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	14 Nov, 2017	Chopped
B	14 Nov, 2017	Chopped
C	14 Nov, 2017	Chopped

CATH Domains (3)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5vp0A00	10 Dec, 2017	1.10.1300.10	Assigned
5vp0B00	10 Dec, 2017	1.10.1300.10	Assigned
5vp0C00	10 Dec, 2017	1.10.1300.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase