PDB 5vkc

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Overview

PDB Information

PDB	5VKC
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity. Bruncko, M., Wang, L., Sheppard, G.S., Phillips, D.C., Tahir, S.K., Xue, J., Erickson, S., Fidanze, S., Fry, E., Hasvold, L., Jenkins, G.J., Jin, S., Judge, R.A., Kovar, P.J., Madar, D., Nimmer, P., Park, C., Petros, A.M., Rosenberg, S.H., Smith, M.L., Song, X., Sun, C., Tao, Z.F., Wang, X., Xiao, Y., Zhang, H., Tse, C., Leverson, J.D., Elmore, S.W., Souers, A.J. J. Med. Chem.
Header	Signaling Protein/Inhibitor
Released	2017-04-21
Resolution	2.310
CATH Insert Date	14 May, 2017

PDB Images (5)

Image of CATH 5vkc

5vkc

PDB 5vkc

Image of CATH 5vkcA

5vkcA

PDB Chain 5vkcA

Image of CATH 5vkcB

5vkcB

PDB Chain 5vkcB

Image of CATH 5vkcA01

5vkcA01

CATH Domain 5vkcA01

Image of CATH 5vkcB01

5vkcB01

CATH Domain 5vkcB01

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	15 May, 2017	Chopped
B	15 May, 2017	Chopped

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5vkcA01	06 Nov, 2017	1.10.437.10	Assigned
5vkcB01	06 Nov, 2017	1.10.437.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1