Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
Wang, L., Pratt, J.K., Soltwedel, T., Sheppard, G.S., Fidanze, S.D., Liu, D., Hasvold, L.A., Mantei, R.A., Holms, J.H., McClellan, W.J., Wendt, M.D., Wada, C., Frey, R., Hansen, T.M., Hubbard, R., Park, C.H., Li, L., Magoc, T.J., Albert, D.H., Lin, X., Warder, S.E., Kovar, P., Huang, X., Wilcox, D., Wang, R., Rajaraman, G., Petros, A.M., Hutchins, C.W., Panchal, S.C., Sun, C., Elmore, S.W., Shen, Y., Kati, W.M., McDaniel, K.F.
J. Med. Chem.