PDB 5tcf

PDB Information

PDB5TCF
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Primary Citation
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Wellington, S., Nag, P.P., Michalska, K., Johnston, S.E., Jedrzejczak, R.P., Kaushik, V.K., Clatworthy, A.E., Siddiqi, N., McCarren, P., Bajrami, B., Maltseva, N.I., Combs, S., Fisher, S.L., Joachimiak, A., Schreiber, S.L., Hung, D.T.
Nat. Chem. Biol.
HeaderLyase
Released2016-09-15
Resolution2.460
CATH Insert Date14 Nov, 2017

PDB Images (21)

PDB Prints

PDB Chains (8)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped

CATH Domains (12)

Domain ID Date inserted into CATH Superfamily CATH Status
5tcfA00 10 Dec, 2017 3.20.20.70 Assigned
5tcfB01 10 Dec, 2017 3.40.50.1100 Assigned
5tcfB02 10 Dec, 2017 3.40.50.1100 Assigned
5tcfC00 10 Dec, 2017 3.20.20.70 Assigned
5tcfD01 10 Dec, 2017 3.40.50.1100 Assigned
5tcfD02 10 Dec, 2017 3.40.50.1100 Assigned
5tcfE00 10 Dec, 2017 3.20.20.70 Assigned
5tcfF01 10 Dec, 2017 3.40.50.1100 Assigned
5tcfF02 10 Dec, 2017 3.40.50.1100 Assigned
5tcfG00 10 Dec, 2017 3.20.20.70 Assigned
5tcfH01 10 Dec, 2017 3.40.50.1100 Assigned
5tcfH02 10 Dec, 2017 3.40.50.1100 Assigned

UniProtKB Entries (8)

Accession Gene ID Taxon Description
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain