PDB 5tbo

PDB Information

PDB5TBO
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli K-12
Gene SourcePlasmodium falciparum (isolate 3D7)
Primary Citation
A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.
Phillips, M.A., White, K.L., Kokkonda, S., Deng, X., White, J., El Mazouni, F., Marsh, K., Tomchick, D.R., Manjalanagara, K., Rudra, K.R., Wirjanata, G., Noviyanti, R., Price, R.N., Marfurt, J., Shackleford, D.M., Chiu, F.C., Campbell, M., Jimenez-Diaz, M.B., Bazaga, S.F., Angulo-Barturen, I., Martinez, M.S., Lafuente-Monasterio, M., Kaminsky, W., Silue, K., Zeeman, A.M., Kocken, C., Leroy, D., Blasco, B., Rossignol, E., Rueckle, T., Matthews, D., Burrows, J.N., Waterson, D., Palmer, M.J., Rathod, P.K., Charman, S.A.
ACS Infect Dis
HeaderOxidoreductase/Oxidoreductase Inhibitor
Released2016-09-12
Resolution2.150
CATH Insert Date16 Oct, 2016

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 17 Oct, 2016 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
5tboA00 21 Oct, 2016 3.20.20.70 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q08210 PYRD_PLAF7 Plasmodium falciparum 3D7 Dihydroorotate dehydrogenase (quinone), mitochondrial