PDB 5t1s

PDB Information

PDB5T1S
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation.
Smith, G.F., Altman, M.D., Andresen, B., Baker, J., Brubaker, J.D., Chen, H., Chen, Y., Childers, M., Donofrio, A., Ferguson, H., Fischer, C., Fischmann, T.O., Gibeau, C., Hicks, A., Jin, S., Kattar, S., Kleinschek, M.A., Leccese, E., Lesburg, C., Li, C., Lim, J., Liu, D., Maclean, J.K.F., Mansoor, F., Moy, L.Y., Mulrooney, E.F., Necheva, A.S., Presland, J., Rakhilina, L., Yang, R., Torres, L., Zhang-Hoover, J., Northrup, A.
Bioorg. Med. Chem. Lett.
HeaderTransferase/Transferase Inhibitor
Released2016-08-22
Resolution2.300
CATH Insert Date14 May, 2017

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 15 May, 2017 Chopped
B 15 May, 2017 Chopped
C 15 May, 2017 Chopped
D 15 May, 2017 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
5t1sA01 12 Jul, 2018 3.30.200.20 Assigned
5t1sA02 12 Jul, 2018 1.10.510.10 Assigned
5t1sB01 12 Jul, 2018 3.30.200.20 Assigned
5t1sB02 12 Jul, 2018 1.10.510.10 Assigned
5t1sC01 12 Jul, 2018 3.30.200.20 Assigned
5t1sC02 12 Jul, 2018 1.10.510.10 Assigned
5t1sD01 12 Jul, 2018 3.30.200.20 Assigned
5t1sD02 12 Jul, 2018 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4