PDB 5nw2

PDB Information

PDB5NW2
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
Soares, P., Gadd, M.S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., Rocha, S., Read, K.D., Ciulli, A.
J. Med. Chem.
HeaderLigase
Released2017-05-04
Resolution2.200
CATH Insert Date14 Nov, 2017

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped
I 14 Nov, 2017 Chopped
J 14 Nov, 2017 Chopped
K 14 Nov, 2017 Chopped
L 14 Nov, 2017 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5nw2A00 10 Dec, 2017 3.10.20.90 Assigned
5nw2B00 10 Dec, 2017 3.30.710.10 Assigned
5nw2C01 10 Dec, 2017 2.60.40.780 Assigned
5nw2C02 10 Dec, 2017 1.10.750.10 Assigned
5nw2D00 10 Dec, 2017 3.10.20.90 Assigned
5nw2E00 10 Dec, 2017 3.30.710.10 Assigned
5nw2F01 10 Dec, 2017 2.60.40.780 Assigned
5nw2F02 10 Dec, 2017 1.10.750.10 Assigned
5nw2G00 10 Dec, 2017 3.10.20.90 Assigned
5nw2H00 10 Dec, 2017 3.30.710.10 Assigned
5nw2I01 10 Dec, 2017 2.60.40.780 Assigned
5nw2I02 10 Dec, 2017 1.10.750.10 Assigned
5nw2J00 10 Dec, 2017 3.10.20.90 Assigned
5nw2K00 10 Dec, 2017 3.30.710.10 Assigned
5nw2L01 10 Dec, 2017 2.60.40.780 Assigned
5nw2L02 10 Dec, 2017 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B