PDB 5nvy
PDB Information
| PDB | 5NVY |
| Method | X-RAY DIFFRACTION |
| Host Organism | Escherichia coli |
| Gene Source | Homo sapiens |
| Primary Citation | Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
J. Med. Chem.
|
| Header | Ligase |
| Released | 2017-05-04 |
| Resolution | 2.900 |
| CATH Insert Date | 14 Nov, 2017 |
PDB Images (29)
5nvy
PDB 5nvy
5nvyA
PDB Chain 5nvyA
5nvyB
PDB Chain 5nvyB
5nvyC
PDB Chain 5nvyC
5nvyD
PDB Chain 5nvyD
5nvyE
PDB Chain 5nvyE
5nvyF
PDB Chain 5nvyF
5nvyG
PDB Chain 5nvyG
5nvyH
PDB Chain 5nvyH
5nvyI
PDB Chain 5nvyI
5nvyJ
PDB Chain 5nvyJ
5nvyK
PDB Chain 5nvyK
5nvyL
PDB Chain 5nvyL
5nvyA00
CATH Domain 5nvyA00
5nvyB00
CATH Domain 5nvyB00
5nvyC01
CATH Domain 5nvyC01
5nvyC02
CATH Domain 5nvyC02
5nvyD00
CATH Domain 5nvyD00
5nvyE00
CATH Domain 5nvyE00
5nvyF01
CATH Domain 5nvyF01
5nvyF02
CATH Domain 5nvyF02
5nvyG00
CATH Domain 5nvyG00
5nvyH00
CATH Domain 5nvyH00
5nvyI01
CATH Domain 5nvyI01
5nvyI02
CATH Domain 5nvyI02
5nvyJ00
CATH Domain 5nvyJ00
5nvyK00
CATH Domain 5nvyK00
5nvyL01
CATH Domain 5nvyL01
5nvyL02
CATH Domain 5nvyL02
PDB Prints
PDB Chains (12)
| Chain ID | Date inserted into CATH | CATH Status |
|---|---|---|
| A | 14 Nov, 2017 | Chopped |
| B | 14 Nov, 2017 | Chopped |
| C | 14 Nov, 2017 | Chopped |
| D | 14 Nov, 2017 | Chopped |
| E | 14 Nov, 2017 | Chopped |
| F | 14 Nov, 2017 | Chopped |
| G | 14 Nov, 2017 | Chopped |
| H | 14 Nov, 2017 | Chopped |
| I | 14 Nov, 2017 | Chopped |
| J | 14 Nov, 2017 | Chopped |
| K | 14 Nov, 2017 | Chopped |
| L | 14 Nov, 2017 | Chopped |
CATH Domains (16)
| Domain ID | Date inserted into CATH | Superfamily | CATH Status |
|---|---|---|---|
| 5nvyA00 | 10 Dec, 2017 | 3.10.20.90 | Assigned |
| 5nvyB00 | 10 Dec, 2017 | 3.30.710.10 | Assigned |
| 5nvyC01 | 10 Dec, 2017 | 2.60.40.780 | Assigned |
| 5nvyC02 | 10 Dec, 2017 | 1.10.750.10 | Assigned |
| 5nvyD00 | 10 Dec, 2017 | 3.10.20.90 | Assigned |
| 5nvyE00 | 10 Dec, 2017 | 3.30.710.10 | Assigned |
| 5nvyF01 | 10 Dec, 2017 | 2.60.40.780 | Assigned |
| 5nvyF02 | 10 Dec, 2017 | 1.10.750.10 | Assigned |
| 5nvyG00 | 10 Dec, 2017 | 3.10.20.90 | Assigned |
| 5nvyH00 | 10 Dec, 2017 | 3.30.710.10 | Assigned |
| 5nvyI01 | 10 Dec, 2017 | 2.60.40.780 | Assigned |
| 5nvyI02 | 10 Dec, 2017 | 1.10.750.10 | Assigned |
| 5nvyJ00 | 10 Dec, 2017 | 3.10.20.90 | Assigned |
| 5nvyK00 | 10 Dec, 2017 | 3.30.710.10 | Assigned |
| 5nvyL01 | 10 Dec, 2017 | 2.60.40.780 | Assigned |
| 5nvyL02 | 10 Dec, 2017 | 1.10.750.10 | Assigned |
UniProtKB Entries (12)
| Accession | Gene ID | Taxon | Description |
|---|---|---|---|
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
