PDB 5nvy

PDB Information

PDB5NVY
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
Soares, P., Gadd, M.S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., Rocha, S., Read, K.D., Ciulli, A.
J. Med. Chem.
HeaderLigase
Released2017-05-04
Resolution2.900
CATH Insert Date14 Nov, 2017

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped
I 14 Nov, 2017 Chopped
J 14 Nov, 2017 Chopped
K 14 Nov, 2017 Chopped
L 14 Nov, 2017 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5nvyA00 10 Dec, 2017 3.10.20.90 Assigned
5nvyB00 10 Dec, 2017 3.30.710.10 Assigned
5nvyC01 10 Dec, 2017 2.60.40.780 Assigned
5nvyC02 10 Dec, 2017 1.10.750.10 Assigned
5nvyD00 10 Dec, 2017 3.10.20.90 Assigned
5nvyE00 10 Dec, 2017 3.30.710.10 Assigned
5nvyF01 10 Dec, 2017 2.60.40.780 Assigned
5nvyF02 10 Dec, 2017 1.10.750.10 Assigned
5nvyG00 10 Dec, 2017 3.10.20.90 Assigned
5nvyH00 10 Dec, 2017 3.30.710.10 Assigned
5nvyI01 10 Dec, 2017 2.60.40.780 Assigned
5nvyI02 10 Dec, 2017 1.10.750.10 Assigned
5nvyJ00 10 Dec, 2017 3.10.20.90 Assigned
5nvyK00 10 Dec, 2017 3.30.710.10 Assigned
5nvyL01 10 Dec, 2017 2.60.40.780 Assigned
5nvyL02 10 Dec, 2017 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15370 ELOB_HUMAN Homo sapiens Elongin-B