PDB 5nvw

PDB Information

PDB5NVW
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
Soares, P., Gadd, M.S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., Rocha, S., Read, K.D., Ciulli, A.
J. Med. Chem.
HeaderLigase
Released2017-05-04
Resolution2.200
CATH Insert Date14 Nov, 2017

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped
I 14 Nov, 2017 Chopped
J 14 Nov, 2017 Chopped
K 14 Nov, 2017 Chopped
L 14 Nov, 2017 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5nvwA00 10 Dec, 2017 3.10.20.90 Assigned
5nvwB00 10 Dec, 2017 3.30.710.10 Assigned
5nvwC01 10 Dec, 2017 2.60.40.780 Assigned
5nvwC02 10 Dec, 2017 1.10.750.10 Assigned
5nvwD00 10 Dec, 2017 3.10.20.90 Assigned
5nvwE00 10 Dec, 2017 3.30.710.10 Assigned
5nvwF01 10 Dec, 2017 2.60.40.780 Assigned
5nvwF02 10 Dec, 2017 1.10.750.10 Assigned
5nvwG00 10 Dec, 2017 3.10.20.90 Assigned
5nvwH00 10 Dec, 2017 3.30.710.10 Assigned
5nvwI01 10 Dec, 2017 2.60.40.780 Assigned
5nvwI02 10 Dec, 2017 1.10.750.10 Assigned
5nvwJ00 10 Dec, 2017 3.10.20.90 Assigned
5nvwK00 10 Dec, 2017 3.30.710.10 Assigned
5nvwL01 10 Dec, 2017 2.60.40.780 Assigned
5nvwL02 10 Dec, 2017 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor