PDB 5m8g

PDB Information

PDB5M8G
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceRattus norvegicus
Primary Citation
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Bohnacker, T., Prota, A.E., Beaufils, F., Burke, J.E., Melone, A., Inglis, A.J., Rageot, D., Sele, A.M., Cmiljanovic, V., Cmiljanovic, N., Bargsten, K., Aher, A., Akhmanova, A., Diaz, J.F., Fabbro, D., Zvelebil, M., Williams, R.L., Steinmetz, M.O., Wymann, M.P.
Nat Commun
HeaderCell Cycle
Released2016-10-28
Resolution2.150
CATH Insert Date07 May, 2017

PDB Images (23)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped
B 08 May, 2017 Chopped
C 08 May, 2017 Chopped
D 08 May, 2017 Chopped
E 08 May, 2017 Chopped
F 08 May, 2017 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5m8gA01 16 May, 2017 3.40.50.1440 Assigned
5m8gA02 16 May, 2017 3.30.1330.20 Assigned
5m8gA03 16 May, 2017 1.10.287.600 Assigned
5m8gB01 16 May, 2017 3.40.50.1440 Assigned
5m8gB02 16 May, 2017 3.30.1330.20 Assigned
5m8gB03 16 May, 2017 1.10.287.600 Assigned
5m8gC01 16 May, 2017 3.40.50.1440 Assigned
5m8gC02 16 May, 2017 3.30.1330.20 Assigned
5m8gC03 16 May, 2017 1.10.287.600 Assigned
5m8gD01 16 May, 2017 3.40.50.1440 Assigned
5m8gD02 16 May, 2017 3.30.1330.20 Assigned
5m8gD03 16 May, 2017 1.10.287.600 Assigned
5m8gE01 16 May, 2017 6.10.280.30 Assigned
5m8gF01 16 May, 2017 3.40.50.11480 Assigned
5m8gF02 16 May, 2017 3.30.470.20 Assigned
5m8gF03 16 May, 2017 3.30.1490.20 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
Q6B856 TBB2B_BOVIN Bos taurus Tubulin beta-2B chain
Q6B856 TBB2B_BOVIN Bos taurus Tubulin beta-2B chain
E1BQ43 E1BQ43_CHICK Gallus gallus Uncharacterized protein
P81947 TBA1B_BOVIN Bos taurus Tubulin alpha-1B chain
P63043 STMN4_RAT Rattus norvegicus Stathmin-4
P81947 TBA1B_BOVIN Bos taurus Tubulin alpha-1B chain