PDB 5m7g

PDB Information

PDB5M7G
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceRattus norvegicus
Primary Citation
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Bohnacker, T., Prota, A.E., Beaufils, F., Burke, J.E., Melone, A., Inglis, A.J., Rageot, D., Sele, A.M., Cmiljanovic, V., Cmiljanovic, N., Bargsten, K., Aher, A., Akhmanova, A., Diaz, J.F., Fabbro, D., Zvelebil, M., Williams, R.L., Steinmetz, M.O., Wymann, M.P.
Nat Commun
HeaderCell Cycle
Released2016-10-27
Resolution2.250
CATH Insert Date07 May, 2017

PDB Images (23)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped
B 08 May, 2017 Chopped
C 08 May, 2017 Chopped
D 08 May, 2017 Chopped
E 08 May, 2017 Chopped
F 08 May, 2017 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5m7gA01 16 May, 2017 3.40.50.1440 Assigned
5m7gA02 16 May, 2017 3.30.1330.20 Assigned
5m7gA03 16 May, 2017 1.10.287.600 Assigned
5m7gB01 15 May, 2017 3.40.50.1440 Assigned
5m7gB02 15 May, 2017 3.30.1330.20 Assigned
5m7gB03 15 May, 2017 1.10.287.600 Assigned
5m7gC01 16 May, 2017 3.40.50.1440 Assigned
5m7gC02 16 May, 2017 3.30.1330.20 Assigned
5m7gC03 16 May, 2017 1.10.287.600 Assigned
5m7gD01 16 May, 2017 3.40.50.1440 Assigned
5m7gD02 16 May, 2017 3.30.1330.20 Assigned
5m7gD03 16 May, 2017 1.10.287.600 Assigned
5m7gE01 16 May, 2017 6.10.280.30 Assigned
5m7gF01 15 May, 2017 3.40.50.11480 Assigned
5m7gF02 15 May, 2017 3.30.470.20 Assigned
5m7gF03 15 May, 2017 3.30.1490.20 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
P81947 TBA1B_BOVIN Bos taurus Tubulin alpha-1B chain
P81947 TBA1B_BOVIN Bos taurus Tubulin alpha-1B chain
E1BQ43 E1BQ43_CHICK Gallus gallus Uncharacterized protein
Q6B856 TBB2B_BOVIN Bos taurus Tubulin beta-2B chain
Q6B856 TBB2B_BOVIN Bos taurus Tubulin beta-2B chain
P63043 STMN4_RAT Rattus norvegicus Stathmin-4