PDB 5m2m

PDB Information

PDB5M2M
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21
Gene SourceHomo sapiens
Primary Citation
Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Beirnaert, E., Desmyter, A., Spinelli, S., Lauwereys, M., Aarden, L., Dreier, T., Loris, R., Silence, K., Pollet, C., Cambillau, C., de Haard, H.
Front Immunol
HeaderCytokine
Released2016-10-13
Resolution2.300
CATH Insert Date14 Nov, 2017

PDB Images (25)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped
I 14 Nov, 2017 Chopped
J 14 Nov, 2017 Chopped
M 14 Nov, 2017 Chopped
N 14 Nov, 2017 Chopped

CATH Domains (12)

Domain ID Date inserted into CATH Superfamily CATH Status
5m2mA00 10 Dec, 2017 2.60.120.40 Assigned
5m2mB00 10 Dec, 2017 2.60.120.40 Assigned
5m2mC00 10 Dec, 2017 2.60.120.40 Assigned
5m2mD00 10 Dec, 2017 2.60.40.10 Assigned
5m2mE00 10 Dec, 2017 2.60.40.10 Assigned
5m2mF00 10 Dec, 2017 2.60.40.10 Assigned
5m2mG00 10 Dec, 2017 2.60.120.40 Assigned
5m2mH00 10 Dec, 2017 2.60.40.10 Assigned
5m2mI00 10 Dec, 2017 2.60.120.40 Assigned
5m2mJ00 10 Dec, 2017 2.60.40.10 Assigned
5m2mM00 10 Dec, 2017 2.60.120.40 Assigned
5m2mN00 10 Dec, 2017 2.60.40.10 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
P01375 TNFA_HUMAN Homo sapiens Tumor necrosis factor
P01375 TNFA_HUMAN Homo sapiens Tumor necrosis factor
P01375 TNFA_HUMAN Homo sapiens Tumor necrosis factor
P01375 TNFA_HUMAN Homo sapiens Tumor necrosis factor
P01375 TNFA_HUMAN Homo sapiens Tumor necrosis factor
P01375 TNFA_HUMAN Homo sapiens Tumor necrosis factor