PDB 5lf7

PDB Links
Overview

PDB Information

PDB	5LF7
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Schrader, J., Henneberg, F., Mata, R.A., Tittmann, K., Schneider, T.R., Stark, H., Bourenkov, G., Chari, A. Science
Header	Hydrolase
Released	2016-06-30
Resolution	2.000
CATH Insert Date	04 Sep, 2016

PDB Images (57)

5lf7

PDB 5lf7

5lf7a

PDB Chain 5lf7a

5lf7A

PDB Chain 5lf7A

5lf7b

PDB Chain 5lf7b

5lf7B

PDB Chain 5lf7B

5lf7C

PDB Chain 5lf7C

5lf7D

PDB Chain 5lf7D

5lf7E

PDB Chain 5lf7E

5lf7F

PDB Chain 5lf7F

5lf7G

PDB Chain 5lf7G

5lf7H

PDB Chain 5lf7H

5lf7I

PDB Chain 5lf7I

5lf7J

PDB Chain 5lf7J

5lf7K

PDB Chain 5lf7K

5lf7L

PDB Chain 5lf7L

5lf7M

PDB Chain 5lf7M

5lf7N

PDB Chain 5lf7N

5lf7O

PDB Chain 5lf7O

5lf7P

PDB Chain 5lf7P

5lf7Q

PDB Chain 5lf7Q

5lf7R

PDB Chain 5lf7R

5lf7S

PDB Chain 5lf7S

5lf7T

PDB Chain 5lf7T

5lf7U

PDB Chain 5lf7U

5lf7V

PDB Chain 5lf7V

5lf7W

PDB Chain 5lf7W

5lf7X

PDB Chain 5lf7X

5lf7Y

PDB Chain 5lf7Y

5lf7Z

PDB Chain 5lf7Z

5lf7a00

CATH Domain 5lf7a00

5lf7A00

CATH Domain 5lf7A00

5lf7b00

CATH Domain 5lf7b00

5lf7B00

CATH Domain 5lf7B00

5lf7C00

CATH Domain 5lf7C00

5lf7D00

CATH Domain 5lf7D00

5lf7E00

CATH Domain 5lf7E00

5lf7F00

CATH Domain 5lf7F00

5lf7G00

CATH Domain 5lf7G00

5lf7H00

CATH Domain 5lf7H00

5lf7I00

CATH Domain 5lf7I00

5lf7J00

CATH Domain 5lf7J00

5lf7K00

CATH Domain 5lf7K00

5lf7L00

CATH Domain 5lf7L00

5lf7M00

CATH Domain 5lf7M00

5lf7N00

CATH Domain 5lf7N00

5lf7O00

CATH Domain 5lf7O00

5lf7P00

CATH Domain 5lf7P00

5lf7Q00

CATH Domain 5lf7Q00

5lf7R00

CATH Domain 5lf7R00

5lf7S00

CATH Domain 5lf7S00

5lf7T00

CATH Domain 5lf7T00

5lf7U00

CATH Domain 5lf7U00

5lf7V00

CATH Domain 5lf7V00

5lf7W00

CATH Domain 5lf7W00

5lf7X00

CATH Domain 5lf7X00

5lf7Y00

CATH Domain 5lf7Y00

5lf7Z00

CATH Domain 5lf7Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	05 Sep, 2016	Chopped
A	05 Sep, 2016	Chopped
b	05 Sep, 2016	Chopped
B	05 Sep, 2016	Chopped
C	05 Sep, 2016	Chopped
D	05 Sep, 2016	Chopped
E	05 Sep, 2016	Chopped
F	05 Sep, 2016	Chopped
G	05 Sep, 2016	Chopped
H	05 Sep, 2016	Chopped
I	05 Sep, 2016	Chopped
J	05 Sep, 2016	Chopped
K	05 Sep, 2016	Chopped
L	05 Sep, 2016	Chopped
M	05 Sep, 2016	Chopped
N	05 Sep, 2016	Chopped
O	05 Sep, 2016	Chopped
P	05 Sep, 2016	Chopped
Q	05 Sep, 2016	Chopped
R	05 Sep, 2016	Chopped
S	05 Sep, 2016	Chopped
T	05 Sep, 2016	Chopped
U	05 Sep, 2016	Chopped
V	05 Sep, 2016	Chopped
W	05 Sep, 2016	Chopped
X	05 Sep, 2016	Chopped
Y	05 Sep, 2016	Chopped
Z	05 Sep, 2016	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5lf7a00	09 Sep, 2016	3.60.20.10	Assigned
5lf7A00	09 Sep, 2016	3.60.20.10	Assigned
5lf7b00	20 Oct, 2016	3.60.20.10	Assigned
5lf7B00	09 Sep, 2016	3.60.20.10	Assigned
5lf7C00	09 Sep, 2016	3.60.20.10	Assigned
5lf7D00	09 Sep, 2016	3.60.20.10	Assigned
5lf7E00	09 Sep, 2016	3.60.20.10	Assigned
5lf7F00	09 Sep, 2016	3.60.20.10	Assigned
5lf7G00	09 Sep, 2016	3.60.20.10	Assigned
5lf7H00	09 Sep, 2016	3.60.20.10	Assigned
5lf7I00	09 Sep, 2016	3.60.20.10	Assigned
5lf7J00	09 Sep, 2016	3.60.20.10	Assigned
5lf7K00	09 Sep, 2016	3.60.20.10	Assigned
5lf7L00	09 Sep, 2016	3.60.20.10	Assigned
5lf7M00	09 Sep, 2016	3.60.20.10	Assigned
5lf7N00	20 Oct, 2016	3.60.20.10	Assigned
5lf7O00	09 Sep, 2016	3.60.20.10	Assigned
5lf7P00	09 Sep, 2016	3.60.20.10	Assigned
5lf7Q00	09 Sep, 2016	3.60.20.10	Assigned
5lf7R00	09 Sep, 2016	3.60.20.10	Assigned
5lf7S00	09 Sep, 2016	3.60.20.10	Assigned
5lf7T00	09 Sep, 2016	3.60.20.10	Assigned
5lf7U00	09 Sep, 2016	3.60.20.10	Assigned
5lf7V00	09 Sep, 2016	3.60.20.10	Assigned
5lf7W00	09 Sep, 2016	3.60.20.10	Assigned
5lf7X00	09 Sep, 2016	3.60.20.10	Assigned
5lf7Y00	09 Sep, 2016	3.60.20.10	Assigned
5lf7Z00	09 Sep, 2016	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6