PDB 5lf3

PDB Links
Overview

PDB Information

PDB	5LF3
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Schrader, J., Henneberg, F., Mata, R.A., Tittmann, K., Schneider, T.R., Stark, H., Bourenkov, G., Chari, A. Science
Header	Hydrolase
Released	2016-06-30
Resolution	2.100
CATH Insert Date	04 Sep, 2016

PDB Images (57)

5lf3

PDB 5lf3

5lf3a

PDB Chain 5lf3a

5lf3A

PDB Chain 5lf3A

5lf3b

PDB Chain 5lf3b

5lf3B

PDB Chain 5lf3B

5lf3C

PDB Chain 5lf3C

5lf3D

PDB Chain 5lf3D

5lf3E

PDB Chain 5lf3E

5lf3F

PDB Chain 5lf3F

5lf3G

PDB Chain 5lf3G

5lf3H

PDB Chain 5lf3H

5lf3I

PDB Chain 5lf3I

5lf3J

PDB Chain 5lf3J

5lf3K

PDB Chain 5lf3K

5lf3L

PDB Chain 5lf3L

5lf3M

PDB Chain 5lf3M

5lf3N

PDB Chain 5lf3N

5lf3O

PDB Chain 5lf3O

5lf3P

PDB Chain 5lf3P

5lf3Q

PDB Chain 5lf3Q

5lf3R

PDB Chain 5lf3R

5lf3S

PDB Chain 5lf3S

5lf3T

PDB Chain 5lf3T

5lf3U

PDB Chain 5lf3U

5lf3V

PDB Chain 5lf3V

5lf3W

PDB Chain 5lf3W

5lf3X

PDB Chain 5lf3X

5lf3Y

PDB Chain 5lf3Y

5lf3Z

PDB Chain 5lf3Z

5lf3a00

CATH Domain 5lf3a00

5lf3A00

CATH Domain 5lf3A00

5lf3b00

CATH Domain 5lf3b00

5lf3B00

CATH Domain 5lf3B00

5lf3C00

CATH Domain 5lf3C00

5lf3D00

CATH Domain 5lf3D00

5lf3E00

CATH Domain 5lf3E00

5lf3F00

CATH Domain 5lf3F00

5lf3G00

CATH Domain 5lf3G00

5lf3H00

CATH Domain 5lf3H00

5lf3I00

CATH Domain 5lf3I00

5lf3J00

CATH Domain 5lf3J00

5lf3K00

CATH Domain 5lf3K00

5lf3L00

CATH Domain 5lf3L00

5lf3M00

CATH Domain 5lf3M00

5lf3N00

CATH Domain 5lf3N00

5lf3O00

CATH Domain 5lf3O00

5lf3P00

CATH Domain 5lf3P00

5lf3Q00

CATH Domain 5lf3Q00

5lf3R00

CATH Domain 5lf3R00

5lf3S00

CATH Domain 5lf3S00

5lf3T00

CATH Domain 5lf3T00

5lf3U00

CATH Domain 5lf3U00

5lf3V00

CATH Domain 5lf3V00

5lf3W00

CATH Domain 5lf3W00

5lf3X00

CATH Domain 5lf3X00

5lf3Y00

CATH Domain 5lf3Y00

5lf3Z00

CATH Domain 5lf3Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	05 Sep, 2016	Chopped
A	05 Sep, 2016	Chopped
b	05 Sep, 2016	Chopped
B	05 Sep, 2016	Chopped
C	05 Sep, 2016	Chopped
D	05 Sep, 2016	Chopped
E	05 Sep, 2016	Chopped
F	05 Sep, 2016	Chopped
G	05 Sep, 2016	Chopped
H	05 Sep, 2016	Chopped
I	05 Sep, 2016	Chopped
J	05 Sep, 2016	Chopped
K	05 Sep, 2016	Chopped
L	05 Sep, 2016	Chopped
M	05 Sep, 2016	Chopped
N	05 Sep, 2016	Chopped
O	05 Sep, 2016	Chopped
P	05 Sep, 2016	Chopped
Q	05 Sep, 2016	Chopped
R	05 Sep, 2016	Chopped
S	05 Sep, 2016	Chopped
T	05 Sep, 2016	Chopped
U	05 Sep, 2016	Chopped
V	05 Sep, 2016	Chopped
W	05 Sep, 2016	Chopped
X	05 Sep, 2016	Chopped
Y	05 Sep, 2016	Chopped
Z	05 Sep, 2016	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5lf3a00	09 Sep, 2016	3.60.20.10	Assigned
5lf3A00	09 Sep, 2016	3.60.20.10	Assigned
5lf3b00	20 Oct, 2016	3.60.20.10	Assigned
5lf3B00	09 Sep, 2016	3.60.20.10	Assigned
5lf3C00	09 Sep, 2016	3.60.20.10	Assigned
5lf3D00	09 Sep, 2016	3.60.20.10	Assigned
5lf3E00	09 Sep, 2016	3.60.20.10	Assigned
5lf3F00	09 Sep, 2016	3.60.20.10	Assigned
5lf3G00	09 Sep, 2016	3.60.20.10	Assigned
5lf3H00	09 Sep, 2016	3.60.20.10	Assigned
5lf3I00	09 Sep, 2016	3.60.20.10	Assigned
5lf3J00	09 Sep, 2016	3.60.20.10	Assigned
5lf3K00	09 Sep, 2016	3.60.20.10	Assigned
5lf3L00	09 Sep, 2016	3.60.20.10	Assigned
5lf3M00	09 Sep, 2016	3.60.20.10	Assigned
5lf3N00	20 Oct, 2016	3.60.20.10	Assigned
5lf3O00	09 Sep, 2016	3.60.20.10	Assigned
5lf3P00	09 Sep, 2016	3.60.20.10	Assigned
5lf3Q00	09 Sep, 2016	3.60.20.10	Assigned
5lf3R00	09 Sep, 2016	3.60.20.10	Assigned
5lf3S00	09 Sep, 2016	3.60.20.10	Assigned
5lf3T00	09 Sep, 2016	3.60.20.10	Assigned
5lf3U00	09 Sep, 2016	3.60.20.10	Assigned
5lf3V00	09 Sep, 2016	3.60.20.10	Assigned
5lf3W00	09 Sep, 2016	3.60.20.10	Assigned
5lf3X00	09 Sep, 2016	3.60.20.10	Assigned
5lf3Y00	09 Sep, 2016	3.60.20.10	Assigned
5lf3Z00	09 Sep, 2016	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7