PDB 5lay

PDB Information

PDB5LAY
MethodX-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation
Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction.
Gollner, A., Rudolph, D., Arnhof, H., Bauer, M., Blake, S.M., Boehmelt, G., Cockroft, X.L., Dahmann, G., Ettmayer, P., Gerstberger, T., Karolyi-Oezguer, J., Kessler, D., Kofink, C., Ramharter, J., Rinnenthal, J., Savchenko, A., Schnitzer, R., Weinstabl, H., Weyer-Czernilofsky, U., Wunberg, T., McConnell, D.B.
J. Med. Chem.
HeaderLigase
Released2016-06-15
Resolution2.710
CATH Insert Date20 Nov, 2016

PDB Images (13)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 21 Nov, 2016 Chopped
B 21 Nov, 2016 Chopped
C 21 Nov, 2016 Chopped
D 21 Nov, 2016 Chopped
E 21 Nov, 2016 Chopped
F 21 Nov, 2016 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
5layA00 25 Nov, 2016 1.10.245.10 Assigned
5layB00 25 Nov, 2016 1.10.245.10 Assigned
5layC00 25 Nov, 2016 1.10.245.10 Assigned
5layD00 25 Nov, 2016 1.10.245.10 Assigned
5layE00 25 Nov, 2016 1.10.245.10 Assigned
5layF00 25 Nov, 2016 1.10.245.10 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2