Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).
Bradbury, R.H., Callis, R., Carr, G.R., Chen, H., Clark, E., Feron, L., Glossop, S., Graham, M.A., Hattersley, M., Jones, C., Lamont, S.G., Ouvry, G., Patel, A., Patel, J., Rabow, A.A., Roberts, C.A., Stokes, S., Stratton, N., Walker, G.E., Ward, L., Whalley, D., Whittaker, D., Wrigley, G., Waring, M.J.
J.Med.Chem.