PDB Information

PDB5I96
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.
Yen, K., Travins, J., Wang, F., David, M.D., Artin, E., Straley, K., Padyana, A., Gross, S., DeLaBarre, B., Tobin, E., Chen, Y., Nagaraja, R., Choe, S., Jin, L., Konteatis, Z., Cianchetta, G., Saunders, J.O., Salituro, F.G., Quivoron, C., Opolon, P., Bawa, O., Saada, V., Paci, A., Broutin, S., Bernard, O.A., de Botton, S., Marteyn, B.S., Pilichowska, M., Xu, Y., Fang, C., Jiang, F., Wei, W., Jin, S., Silverman, L., Liu, W., Yang, H., Dang, L., Dorsch, M., Penard-Lacronique, V., Biller, S.A., Su, S.M.
Cancer Discov
HeaderOxidoreductase/Oxidoreductase Inhibitor
Released2016-02-19
Resolution1.550
CATH Insert Date07 May, 2017

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped
B 08 May, 2017 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5i96A00 12 May, 2017 3.40.718.10 Assigned
5i96B00 12 May, 2017 3.40.718.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P48735 IDHP_HUMAN Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial
P48735 IDHP_HUMAN Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial