PDB Information

PDB5HI5
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
Liu, S., Dakin, L.A., Xing, L., Withka, J.M., Sahasrabudhe, P.V., Li, W., Banker, M.E., Balbo, P., Shanker, S., Chrunyk, B.A., Guo, Z., Chen, J.M., Young, J.A., Bai, G., Starr, J.T., Wright, S.W., Bussenius, J., Tan, S., Gopalsamy, A., Lefker, B.A., Vincent, F., Jones, L.H., Xu, H., Hoth, L.R., Geoghegan, K.F., Qiu, X., Bunnage, M.E., Thorarensen, A.
Sci Rep
HeaderImmune System/Inhibitor
Released2016-01-11
Resolution1.800
CATH Insert Date02 Oct, 2016

PDB Images (18)

PDB Prints

PDB Chains (7)

Chain ID Date inserted into CATH CATH Status
A 03 Oct, 2016 Chopped
B 03 Oct, 2016 Chopped
C 03 Oct, 2016 Chopped
D 03 Oct, 2016 Chopped
H 03 Oct, 2016 Chopped
I 03 Oct, 2016 Rejected
L 03 Oct, 2016 Chopped

CATH Domains (10)

Domain ID Date inserted into CATH Superfamily CATH Status
5hi5A01 07 Oct, 2016 2.10.90.10 Assigned
5hi5B00 06 Oct, 2016 2.10.90.10 Assigned
5hi5C01 07 Oct, 2016 2.60.40.10 Assigned
5hi5C02 07 Oct, 2016 2.60.40.10 Assigned
5hi5D01 07 Oct, 2016 2.60.40.10 Assigned
5hi5D02 07 Oct, 2016 2.60.40.10 Assigned
5hi5H01 07 Oct, 2016 2.60.40.10 Assigned
5hi5H02 07 Oct, 2016 2.60.40.10 Assigned
5hi5L01 07 Oct, 2016 2.60.40.10 Assigned
5hi5L02 07 Oct, 2016 2.60.40.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q16552 IL17_HUMAN Homo sapiens Interleukin-17A
Q16552 IL17_HUMAN Homo sapiens Interleukin-17A