PDB 5hex

PDB Information

PDB5HEX
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors.
Lin, H., Zeng, J., Xie, R., Schulz, M.J., Tedesco, R., Qu, J., Erhard, K.F., Mack, J.F., Raha, K., Rendina, A.R., Szewczuk, L.M., Kratz, P.M., Jurewicz, A.J., Cecconie, T., Martens, S., McDevitt, P.J., Martin, J.D., Chen, S.B., Jiang, Y., Nickels, L., Schwartz, B.J., Smallwood, A., Zhao, B., Campobasso, N., Qian, Y., Briand, J., Rominger, C.M., Oleykowski, C., Hardwicke, M.A., Luengo, J.I.
Acs Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2016-01-06
Resolution2.730
CATH Insert Date10 Apr, 2016

PDB Images (11)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 11 Apr, 2016 Chopped
B 11 Apr, 2016 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
5hexA01 21 Feb, 2018 3.40.367.20 Assigned
5hexA02 21 Feb, 2018 3.30.420.40 Assigned
5hexA03 21 Feb, 2018 3.40.367.20 Assigned
5hexA04 21 Feb, 2018 3.30.420.40 Assigned
5hexB01 21 Feb, 2018 3.40.367.20 Assigned
5hexB02 21 Feb, 2018 3.30.420.40 Assigned
5hexB03 21 Feb, 2018 3.40.367.20 Assigned
5hexB04 21 Feb, 2018 3.30.420.40 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P52789 HXK2_HUMAN Homo sapiens Hexokinase-2
P52789 HXK2_HUMAN Homo sapiens Hexokinase-2