PDB Information

Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model.
Han, W., Menezes, D.L., Xu, Y., Knapp, M.S., Elling, R., Burger, M.T., Ni, Z.J., Smith, A., Lan, J., Williams, T.E., Verhagen, J., Huh, K., Merritt, H., Chan, J., Kaufman, S., Voliva, C.F., Pecchi, S.
HeaderTransferase/Transferase Inhibitor
CATH Insert Date10 Apr, 2016

PDB Images (10)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 11 Apr, 2016 Chopped
B 11 Apr, 2016 Chopped

CATH Domains (7)

Domain ID Date inserted into CATH Superfamily CATH Status
5fi4A01 12 Jul, 2018 Assigned
5fi4A02 12 Jul, 2018 Assigned
5fi4A03 12 Jul, 2018 Assigned
5fi4A04 12 Jul, 2018 3.30.1010.10 Assigned
5fi4A05 12 Jul, 2018 1.10.1070.11 Assigned
5fi4B01 14 Nov, 2017 Holding pen
5fi4B02 14 Nov, 2017 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P27986 P85A_HUMAN Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit alpha
P42336 PK3CA_HUMAN Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform