PDB Information

PDB5F5I
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
Bavetsias, V., Lanigan, R.M., Ruda, G.F., Atrash, B., McLaughlin, M.G., Tumber, A., Mok, N.Y., Le Bihan, Y.V., Dempster, S., Boxall, K.J., Jeganathan, F., Hatch, S.B., Savitsky, P., Velupillai, S., Krojer, T., England, K.S., Sejberg, J., Thai, C., Donovan, A., Pal, A., Scozzafava, G., Bennett, J.M., Kawamura, A., Johansson, C., Szykowska, A., Gileadi, C., Burgess-Brown, N.A., von Delft, F., Oppermann, U., Walters, Z., Shipley, J., Raynaud, F.I., Westaway, S.M., Prinjha, R.K., Fedorov, O., Burke, R., Schofield, C.J., Westwood, I.M., Bountra, C., Muller, S., van Montfort, R.L., Brennan, P.E., Blagg, J.
J.Med.Chem.
HeaderOxidoreductase
Released2015-12-04
Resolution2.630
CATH Insert Date10 Jan, 2016

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 11 Jan, 2016 Chopped
B 11 Jan, 2016 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5f5iA01 15 Jan, 2016 2.60.120.650 Assigned
5f5iB01 15 Jan, 2016 2.60.120.650 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
O75164 KDM4A_HUMAN Homo sapiens Lysine-specific demethylase 4A
O75164 KDM4A_HUMAN Homo sapiens Lysine-specific demethylase 4A